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In addition, Hackshaw and colleagues also found that risks of coronary heart disease increased in a dose-response fashion as cigarette consumption increased pooled Hazard Risk (HR, versus never smoker) was 1.4 (95% CI = 1.21.7), 1.5 (95% CI = 1.31.8), and 2.4 (95% CI = 2.12.8) for those who smoked approximately one, five, and 20 cigarettes per day, respectively, based on 16 prospective studies from the US Footnote 3

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The penis has two sponge-like chambers (corpora cavernosa) surrounded by a tough outer layer (tunica albuginea)

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